The University of Delaware / Thomas Jefferson University joint program in Functional Genomics/Computational Biology at the Daniel Baugh Institute
has been established to provide an interdisciplinary base for research and
education in these rapidly emerging computational-biomedical fields.
Research interests of the group center on the development and use of quantitative, (particularly genomic) system-wide datasets
for the study of integrative and adaptive biological (particularly neurobiological) mechanisms.
Research areas include but are not limited to:
- Analysis of genetic regulatory circuits through experiments and computational modeling.
- Mechanisms of sensory integration and system remodeling in adaptive organismic
homeostatic regulation.
- Effects of alcohol on liver, brain, heart and developmental systems involved with addictive
and withdrawl processes.
- Development of functional genomic data acquisition technologies supporting quantitative
modeling of differentiated functions.
- Information theoretic analyses of neuronal information processing.
- Analysis and computational modeling of signaling networks.
- Functional brain imaging.
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Students in the program have the opportunity to assemble their curriculum from a selection of courses at both universities. There is no additional
tution cost and the credits and grades appear on the home institute
academic transcript. Graduate level
courses available include but are not limited to:
| Thomas Jefferson University | University of Delaware |
| Biochemistry: Molecular Building Blocks | Metabolic Engineering |
| Biochemistry: Genetic Information Transfer | Biochemical Engineering |
| Biochemistry: Metabolism | Discovery Informatics |
| Cell Biology | High Performance Computing |
| Molecular Pharmacology | Nonlinear Dynamics |
| Introduction to Neuroscience | Optimization |
| Medical Neuroscience | Numerical Techniques |
| Advanced Control |
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Participants in the program will have access to a wide variety of advanced experimental and computational resources.
Laboratory: Daniel Baugh Institute has wet lab facilities for cDNA arrays (robotics, arraying, scanning), laser capture microdissection,
electrophysiology, molecular biology, and histology.
Computational: Sun Enterprise 4500 server w/ 6 CPUs; 12 Gb RAM, 500 Gb Disk, Five Sun Blade-100s, One Sun Blade-1000 on a UNIX network,
internet2 connection and numerous PCs and Macs.
Clinical: The Daniel Baugh Institute is part of the Department of Pathology, Anatomy, and Cell Biology, with access to the
clinical pathology services, especially Surgical Pathology for assistance in cell identification for the laser capture microdissection.
Animal: Animal facilities are in the same building as the laboratories and offices at Thomas Jefferson University. They are AALAC accredited,
and overseen by a licensed veterinarian.
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The program receives funding from a diverse array of agencies, including the
National Institutes of Health, the
National Science Foundation, and the
Defense Advanced Research Projects Agency (DARPA).
Joint research funding for the program between TJU and UD was recently awarded for the grant Multi-Timescale Complex
Adaptation through the DARPA
BIO-COMP initiative.
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Faculty participating in the program have a diverse range of interests and expertise, including systems engineering, metabolic
engineering, parallel computation, signal processing, databases, intracellular signaling, molecular biology, neurobiology,
neuroscience, and electrophysiology.
Please feel free to peruse the web pages of the groups below. Questions and inquiries via email are very welcome.
University of Delaware
Department of Chemical Engineering
Department of Electrical and Computer Engineering
Thomas Jefferson University
Daniel Baugh Institute for Functional Genomics and Computational Biology
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